GOUT

Gout is characterized by sudden, severe attacks of pain, redness and tenderness in joints, often the joint at the base of the big toe. Its common symptoms include intense joint pain, lingering discomfort, inflammation and redness and limited mobility. The overall prevalence of gout in the USA is 3.9%, with an estimated 8.3 million adults affected. The prevalence of hyperuricemia alone amongst US adults is 21.4% or about 43.3 million individuals. Despite the rising prevalence, current therapies are often limited due to side effects, conflicting comorbidities (such as cardiovascular disease, diabetes mellitus, hypertension, chronic kidney disease, metabolic syndrome), and drug-drug interactions.